Latest study shows: Spermidine protects our brain

A new study from the field of molecular and cellular neurobiology at Fujian Medical University shows that spermidine has a protective and regenerative effect on our brain. The study focusses on the effect of spermidine intake after a traumatic brain injury. The results demonstrate how administering spermidine after a brain injury can have positive effects on our brain and its cognitive functions.

Spermidine minimizes the damages caused by craniocerebral trauma.

Spermidine is a polyamine found in our body which plays an important role in brain development and cell renewal. Because of the known positive effects of spermidine on the brain, this study aimed to examine the therapeutic potential of this molecule in craniocerebral injuries .

Traumatic brain injury (TBI) causes permanent neurological and cognitive impairment. However, effective pharmacological interventions remain elusive. In order to investigate the protective function of spermidine in brain injuries, a so-called “closed head injury model” (CHI) has been used, which enables investigating the brain without the influence of external disturbance factors. When measuring the effects of spermidine after craniocerebral trauma, the extent of brain swelling, the function of the blood-brain barrier and apoptosis (cell death) were measured. To monitor the success of the treatment, possible inflammatory processes were observed and biomarkers for brain injury were considered. Lastly, the levels of spermidine with CHI animal model and TBI patients were correlated.

Study results

  • In the spermidine-treated group, improvements in brain swelling and the functioning of the blood-brain barrier were observed.
  • Far fewer neurons died as a result of spermidine administration, thus reducing the extent of apoptosis (cell death).
  • An increase in cognitive brain performance after the brain injury was detected – the brain was able to solve more tasks and generally work faster.
  • There were significantly fewer inflammatory processes in the brain (anti-inflammatory effect).
  • The spermidine content in the test group with severe brain injuries was significantly lower. This suggests that spermidine can prevent or minimize potential brain damage.
  • For the first time it could be demonstrated that the administration of spermidine can be a novel treatment for craniocerebral trauma.


¹ Huang, J., Zhang, H., Zhang, J. et al. Spermidine Exhibits Protective Effects Against Traumatic Brain Injury. Cell Mol Neurobiol (2020), online:

Vedran Bijelac

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